This qualitative research report presents an illustration of Mishel's (1990) reconceptualization of uncertainty in illness theory applied to persons with schizophrenia. The researcher interviewed 6 persons with schizophrenia and 5 family members. The informants reported being uncertain about whether their medicine would keep working, whether they would be able to provide for their children, whether they could stay on their medicine, whether their symptoms would improve, when the next relapse would be, and even whether they would survive. They appeared to be experiencing differing degrees of uncertainty and a variety of manifestations of probabilistic thinking. For some, uncertainty provided the opportunity for hope. For others, the uncertainty was perceived as a danger. For all of them, their view of life had changed.