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Volume 38 Issue 2
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Xenobiotica
The fate and safety evaluation of foreign compounds in biological systems
, Volume
38
Issue 2 2008
ISSN:
1366-5928 (electronic) 0049-8254 (paper)
Publication Frequency:
12 issues per year
Subjects:
Pharmacology
;
Toxicology
;
Publisher:
Informa Healthcare
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Original Articles
Ketoconazole and the modulation of multidrug resistance-mediated transport in Caco-2 and MDCKII-MDR1 drug transport models
Y. Fan; R. Rodriguez-Proteau
Pages 107 – 129
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Molecular modelling study of the mechanism of high-potency inhibition of human catechol-
O
-methyltransferase by (–)-epigallocatechin-3-
O
-gallate
B. T. Zhu; J. -Y. Shim; M. Nagai; H. -W. Bai
Pages 130 – 146
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Effects of dietary salt on the expression of drug transporters, cytochrome P4503a, and nuclear receptors in rats
H. J. Kang; I. S. Song; S. S. Lee; M. A. Yoo; J. G. Shin
Pages 147 – 155
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Metabolism of OR-1896, a metabolite of levosimendan, in rats and humans
M. Koskinen; J. Puttonen; M. Pykäläinen; A. Vuorela; T. Lotta
Pages 156 – 170
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Metabolism and disposition of [
14
C]5-amino-
o
-cresol in female F344 rats and B6C3F1 mice
B. Hedtke; Z. Gao; L. -J. Chen; W. M. Weber; K. J. Dix
Pages 171 – 184
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Preclinical factors affecting the pharmacokinetic behaviour of tanshinone IIA, an investigational new drug isolated from
Salvia miltiorrhiza
for the treatment of ischaemic heart diseases
H. -C. Bi; Z. Zuo; X. Chen; C. -S. Xu; Y. -Y. Wen; H. -Y. Sun; L. -Z. Zhao; Y. Pan; Y. Deng; P. -Q. Liu; L. -Q. Gu; Z. -Y. Huang; S. -F. Zhou; M. Huang
Pages 185 – 222
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Importance of mechanistic drug metabolism studies in support of drug discovery: A case study with an
N
-sulfonylated dipeptide VLA-4 antagonist in rats
W. Tang; R. A. Stearns; Q. Chen; K. Bleasby; Y. Teffera; A. Colletti; M. Hafey; R. Evers; D. C. Dean; P. A. Magriotis; T. J. Lanza; L. S. Lin; W. K. Hagmann; T. A. Baillie
Pages 223 – 237
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