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Amyotrophic Lateral Sclerosis, Volume 5 Supplement 1 2004

Amyotrophic Lateral Sclerosis is moving!
2008 Impact Factor: 1.815 (ISI Web of Knowledge, 2008 Journal Citation Reports)
ISSN: 1471-180X (electronic) 1748-2968 (paper)
Publication Frequency: 6 issues per year
Subject: Neurology;
Previously published as: Amyotrophic Lateral Sclerosis and other Neuron Disorders (1466-0822, 1471-180X) until 2006
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Foreword
Foreword
Gerald D. Fischbach
Page 5
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Introduction
Preface
Hiroshi Mitsumoto; Serge Przedborski
Pages 6 – 7
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Randomized control trials in ALS: lessons learned
Hiroshi Mitsumoto;  Paul Gordon;  Petra Kaufmann;  Clifton Gooch;  Serge Przedborski; Lewis P. Rowland
Pages 8 – 13
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Bench to clinic
Molecular targets for neuroprotection
Serge Przedborski
Pages 14 – 18
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High throughput drug screening
Jill Heemskerk
Pages 19 – 21
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Preclinical studies: how much can we rely on?
Jeffrey D. Rothstein
Pages 22 – 25
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Lessons learned from other neurological diseases
Parkinson's disease
Stanley Fahn
Pages 26 – 30
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Stroke
Jay P. Mohr
Pages 31 – 33
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Neuro-Oncology
S Clifford Schold Jr
Pages 34 – 35
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Issues in Clinical Trials
Regulatory issues in ALS clinical trials
Wilson W. Bryan
Pages 36 – 41
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Randomized controlled trials
John Marler
Page 42
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Statistical issues
Bruce Levin
Pages 43 – 45
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Data Safety Monitoring Board (DSMB)
KMA Welch
Pages 46 – 47
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Missing data
John LP Thompson; Gilberto Levy
Pages 48 – 51
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Study design
ALS trial design: expectation and reality
Robert G. Miller; Dan H. Moore
Pages 52 – 54
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An efficient multi-stage, single-arm Phase II futility design for ALS
Yuko Y. Palesch; Barbara C. Tilley
Pages 55 – 56
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Improving efficiency of ALS clinical trials using lead-in designs
Dan H. Moore II; Robert G. Miller
Pages 57 – 60
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Design using historical controls
Albert Yen;  Ericka Simpson;  Lanny Haverkamp; Stanley Appel
Pages 61 – 63
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Natural history is a moving target
Baseline disease characteristics
P. N. Leigh
Pages 64 – 67
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Disease-modifying drug therapies
Benjamin R. Brooks; Mohammed Sanjak
Pages 68 – 75
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Disease-modifying interventions
Edward Kasarskis
Pages 76 – 78
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Endpoints
Survival
J. Cedarbaum
Pages 79 – 83
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Maximum voluntary isometric contraction (MVIC)
Merit Cudkowicz;  Hui Zhang;  Muhammad Qureshi; David Schoenfeld
Pages 84 – 85
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Assessment of strength measurements
Eric J. Sorensen
Pages 86 – 89
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