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Long-Term Preservation of Vision in Progressive Outer Retinal Necrosis Treated with Combination Antiviral Drugs and Highly Active Antiretroviral Therapy
Authors:
Stephen J. Kim a;
Robert Equi a;
Marie-Lyne Belair a;
Howard F. Fine a;
James P. Dunn b
| Affiliations: | a Wilmer Eye Institute, Ophthalmology, Baltimore, USA |
| b The Johns Hopkins Hospital, The Wilmer Eye Institute, Baltimore, USA |
DOI:
10.1080/09273940701732255
Publication Frequency:
6 issues per year
Subjects:
Allergology & Clinical Immunology;
Ophthalmology;
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Abstract
Purpose: To report the successful long-term treatment of varicella zoster virus-associated progressive outer retinal necrosis (VZV-PORN) with aggressive antiviral combination drugs along with highly active antiretroviral therapy (HAART). Design: Interventional case report. Methods: Combined treatment of progressive outer retinal necrosis in a university-based tertiary eye hospital with ganciclovir implant, intravenous acyclovir (10 mg/kg every 8 h), intravitreal foscarnet (2.4 mg), and HAART. Results: Successful treatment of progressive outer retinal necrosis with disease remission and preservation of 20/20 visual acuity out to 1 year. Conclusions: Combination antiviral therapy and HAART may improve long-term visual outcomes for VZV-PORN.
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| Keywords: ganciclovir implant; HIV; PORN; progressive outer retinal necrosis; varicella-zoster |
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