In this paper, we review European legislation in the field of micronutrient food supplements and find it wanting. It is shown that the precautionary principle, embedded in European food legislation, pre-empts innovative developments in this field. In view of the scientific advances in micronutrients research, we subsequently critique the precautionary perspective and propose a novel outlook on micronutrients food supplements regulation. However, this requires a transition from the “survival” approach of the current deficiency-related RDAs to a “health-optimization” approach of a n(ew)-RDA. Genomic integrity is central in this envisioned transition.