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Ring-Closing Metathesis Strategies to P -heterocycles 

Authors: Kevin T. Sprott a;  Matthew D. McReynolds a; Paul R. Hanson a
Affiliation:   a Department of Chemistry, University of Kansas, Lawrence, KS.
DOI: 10.1080/10426500212282
Publication Frequency: 12 issues per year
Published in: journal Phosphorus, Sulfur, and Silicon and the Related Elements, Volume 177, Issue 6 & 7 June 2002 , pages 1807 - 1809
Formats available: PDF (English)
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Abstract

A general approach to the synthesis of P -heterocycles using the ring-closing metathesis reaction is described. We have developed a new method utilizing phosphorus nuclei as suitable temporary tethers for the coupling of non-racemic allylic amines. This approach allows for the generation of symmetric and unsymmetric 1,4-diamines. Subsequent coupling of these 1,4-diamines with various nuclei produces an array of 7-membered heterocycles.
Keywords: 1,4-Diamine; P -heterocycle; Ring-closing Metathesis Cyclic Phosphonamide; Temporary Phosphorus Tether
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