Semi-arid wetland areas in Central Spain are especially sensitive ecosystems and are considered to be one of the most important areas for the migration and wintering of waterfowl in Europe. Many of these wetland areas are saline or sub saline and are subjected to natural (seasonal) as well as human induced changes. Factors causing changes that significantly alter or modify the ecological function of these wetlands are considered to be degradation processes. The use of hyperspectral and multispectral data together with ground spectra and field studies has a great potential for monitoring wetland conditions. In this work spectral and analytical information concerning soil, vegetation and land use, contained in a site specific spectral library, is linked with the spectral characteristics of components from an anthropogenic influenced wetland area in La Mancha Alta. This information forms the basis for determining and selecting end members from hyperspectral data (DAIS 7915), which are then extrapolated to lower spatial and spectral resolution multispectral Landsat ETM+ and TM data. A spectral unmixing is carried out to obtain a multitemporal analysis for evaluating wetland degradation. Results show that the approach is successful in determining rapid surface change due to anthropogenic influences. Spectral unmixing results present an increase of salt-affected soil and a redistribution of saline pasture. This is further supported with a post classification change detection assessment and ground data confirm that principal causes are changes in wetland use together with water regulation of the Cigela river.