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The Reactions of 1·0 Nanometre Diameter Plutonium-238 Dioxide Particles with Rat Lung Fluid
Authors:
J.R. Cooper a;
G.N. Stradling a;
H. Smith a;
S.E. Breadmore a
| Affiliation: | a National Radiological Protection Board, Harwell, Didcot, U.K. |
DOI:
10.1080/09553007914551251
Publication Frequency:
12 issues per year
Published in:
International Journal of Radiation Biology,
Volume
36,
Issue
5
November
1979
, pages 453
- 466
International Journal of Radiation Biology,
Volume
36,
Issue
5
November
1979
, pages 453
- 466
Subjects:
Nuclear Medicine;
Radiation Oncology;
Formats available:
PDF
(English)
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Abstract
The reactions of 1·0 nm particles of plutonium-238 dioxide with rat lung fluid have been studied both in vivo and in vitro. In both cases two products have been identified, (i) plutonium-labelled pulmonary surfactant and (ii) a heterogeneous plutonium-labelled material isolated by column chromatography.
The formation of plutonium-labelled pulmonary surfactant results in the rapid translocation of plutonium from lungs to blood and in a high urinary excretion relative to administered plutonium citrate. |
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