By virtue of its large area of exposure of different crustal levels, and preservation of a protracted (∼400 million years) Palaeoproterozoic to Mesoproterozoic tectonic evolution, the Mt Isa Inlier is an excellent natural laboratory to study Proterozoic tectonic processes. The inlier preserves evidence of intracontinental basin development, plutonism, low-pressure metamorphism, orogenesis at different crustal levels, and crustal-scale metasomatism. In addition, the Mt Isa Inlier is endowed with a variety of ore deposits, including the Mt Isa Pb - Zn - Ag and Cu deposits, Century Zn - Pb - Ag deposit, Cannington Ag - Pb - Zn deposit, and the Osborne and Ernest Henry iron oxide Cu - Au deposits. Basement rocks were deformed and metamorphosed during the ca 1900 - 1870 Ma Barramundi Orogeny and intruded by the granitic rocks of the ca 1850 Ma Kalkadoon and Ewen Batholiths and their coeval Leichhardt Volcanics. Three stacked and superimposed superbasins evolved between ca 1800 and ca 1595 Ma. These basins evolved in an environment characterised by elevated heat flow and transient episodes of magmatism and basin inversion in an inferred continental backarc setting. The ca 1600 - 1500 Ma Isan Orogeny probably records two phases of orogenesis. The first phase (ca 1600 - 1570 Ma) involved approximately north - south to northwest - southeast shortening in which a northwest-vergent fold-thrust belt evolved in the Eastern Fold Belt and localised basin inversion occurred in the Western Fold Belt. The second phase (ca 1550 - 1500) involved thick-skinned deformation in the Eastern and Western Fold Belts, characterised by upright folding, reverse faulting, and dextral wrenching. Voluminous granites were emplaced throughout the Eastern Fold Belt between ca 1550 and 1500 Ma. Exhumation and cooling of the crustal pile following the Isan Orogeny were related to crustal extension and widespread erosion in eastern and southern Australia. Subtle reactivation of faults within the inlier following the Isan Orogeny records the distal effects of Mesoproterozoic to Neoproterozoic breakup events and orogenesis in central Australia.