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Evaluation of Rate of Swelling and Erosion of Verapamil (VRP) Sustained-Release Matrix Tablets 

Authors: Sandile M. Khamanga a; Roderick B. Walker a
Affiliation:   a Faculty of Pharmacy, Rhodes University, Grahamstown, South Africa
DOI: 10.1080/03639040600599822
Publication Frequency: 12 issues per year
Published in: journal Drug Development and Industrial Pharmacy, Volume 32, Issue 10 December 2006 , pages 1139 - 1148
Formats available: HTML (English) : PDF (English)
Also incorporating: Drug Design and Discovery
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Abstract

Tablets manufactured in-house were compared to a marketed sustained-release product of verapamil to investigate the rate of hydration, erosion, and drug-release mechanism by measuring the wet and subsequent dry weights of the products. Swelling and erosion rates depended on the polymer and granulating fluid used, which ultimately pointed to their permeability characteristics. Erosion rate of the marketed product was highest, which suggests that the gel layer that formed around these tablets was weak as opposed to the robust and resistant layers of test products. Anomalous and near zero-order transport mechanisms were dominant in tests and commercial product, respectively.
Keywords: Verapamil hydrochloride; Swelling; Erosion; Drug release; Surelease; Eudragit
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