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Measuring recovery in new learning and memory following traumatic brain injury: A mixed-effects modeling approach 

Authors: Bong-Chul Chua; Scott Millisb; Juan Carlos Arango-Lasprillacd; Robin Hanksb; Thomas Novacke; Tessa Hartf
Affiliations:   a The Medstat Group, Santa Barbara, CA, USA
b Wayne State University School of Medicine, Detroit, MI, USA
c Department of Physical Medicine and Rehabilitation, University of Medicine and Dentistry of New Jersey, West Orange, NJ, USA
d Kessler Medical Rehabilitation Research and Education Corporation, West Orange, NJ, USA
e Rehabilitation Institute of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA
f Moss Rehabilitation Research Institute, Philadelphia, PA, USA
DOI: 10.1080/13803390600878893
Publication Frequency: 10 issues per year
Published in: journal Journal of Clinical and Experimental Neuropsychology, Volume 29, Issue 6 August 2007 , pages 617 - 625
First Published: August 2007
Formats available: HTML (English) : PDF (English)
Previously published as: Journal of Clinical and Experimental Neuropsychology (0168-8634) until 1994
Previously published as: Journal of Clinical Neuropsychology (0165-0475) until 1985
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Abstract

Patterns of recovery from traumatic brain injury (TBI) vary greatly across individuals. Using archival data from the Traumatic Brain Injury Model Systems, recovery of memory following TBI as measured by scores on the Rey Auditory Verbal Learning Test (RAVLT) through 5 years postinjury was examined via mixed-effects modeling. Individual-level variables of age and posttraumatic amnesia duration were significant predictors of 1-year RAVLT total score. None of the variables examined predicted the trajectory of memory recovery after 1 year. Mixed-effects analyses can be helpful in determining the effect of intervention while allowing for missing data across time points.
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