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Traditional kava beverage consumption and liver function tests in a predominantly Tongan population in Hawaii 

Authors: Amy C. Brown abc;  Janet Onopa bcd;  Peter Holck bc;  Pakieli Kaufusi bc;  Derek Kabasawa c;  Winston J. Craig e;  Klaus Dragull cf;  Arieh M. Levine cg; Jonathan D. Baker cg
Affiliations:   a Department of Complementary & Alternative Medicine, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, Hawaii, USA
b John A. Burns School of Medicine, Honolulu, Hawaii, USA
c University of Hawaii at Manoa, Honolulu, Hawaii, USA
d Department of Medicine, Honolulu, Hawaii, USA
e Department of Nutrition & Wellness, Andrews University, Berrien Springs, Michigan, USA
f Department of Molecular Biosciences and Bioengineering, Honolulu, Hawaii, USA
g Department of Anthropology, Honolulu, Hawaii, USA
DOI: 10.1080/15563650701365875
Publication Frequency: 10 issues per year
Published in: journal Clinical Toxicology, Volume 45, Issue 5 June 2007 , pages 549 - 556
Formats available: HTML (English) : PDF (English)
Previously published as: Journal of Toxicology: Clinical Toxicology (0731-3810) until 2005
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Abstract

Purpose. To determine the effects of traditionally prepared kava beverages on the liver function tests of regular kava beverage consumers in a population of Tongan and non-Tongan residents of Hawaii (Oahu). Methods. The liver function tests of 31 healthy adult kava drinkers were compared against a control group of 31 healthy adult non-kava drinkers. Subjects were recruited from the general population, a kava bar, and Tongan kava drinking circles. The liver function profile included AST, ALT, ALP, GGT, and bilirubin (total and direct). Other tests included total protein, albumin, and screens for viral hepatitis and hemochromatosis when indicated. Results. Chronic kava beverage consumption was associated with elevation of GGT in 65% of the kava drinkers versus 26% in the controls (P = .005). ALP was elevated in 23% of kava drinkers versus 3% in the controls (P = .053). Conclusion. Heavy kava beverage consumption was associated with significantly elevated GGT levels.
Keywords: Kava; Beverage; Liver function test; Hepatotoxicity; Pacific Islanders
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