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Synthesis and antiproliferative activity of some diaryldiazepines and diarylpyrimidines
Authors:
R. Ramajayam a;
Rajani Giridhar a;
Mange Ram Yadav a;
Hakim Djaballah b;
David Shum b;
Constantin Radu b
| Affiliations: | a Pharmacy Department, Faculty of Technology and Engineering, Kalabhavan, The M.S University of Baroda, Vadodara, India |
| b HTS Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY, USA |
DOI:
10.1080/14756360701306073
Publication Frequency:
6 issues per year
Published in:
Journal of Enzyme Inhibition and Medicinal Chemistry,
Volume
22,
Issue
6
December
2007
, pages 716
- 721
First Published:
December
2007
Journal of Enzyme Inhibition and Medicinal Chemistry,
Volume
22,
Issue
6
December
2007
, pages 716
- 721
Subjects:
Cell Biology;
Medicinal & Pharmaceutical Chemistry;
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Abstract
Novel substituted 5,7-diaryl-2,3-dihydro-1,4-diazepines and 4,6-diaryl-2-aminopyrimidines were synthesized and tested for their antiproliferative activity. Title compounds were obtained by cyclocondensation of a substituted flavone with ethylenediamine and guanidine respectively. The cytotoxicity in vitro against various human leukemic cancer cell lines viz., Jurkat, HL60, MOLT3, NCEB-1, K562 was determined.
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| Keywords: diaryldiazepines; diarylpyrimidines; antiproliferative activity |
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