A study is made on a proton exchange membrane (PEM) fuel cell that supports a new type of chemical coupling of 2-propanol/acetone/hydrogen to generate power. Power generation that uses this new chemical coupling of reactions requires specific types of catalysts in the fuel cell. In the present paper, investigations of a few catalysts and systematic metallic loading from different precursors in various loading ratios on carbon electrodes have been conducted to maximize current generation. Various permutations of catalysts (pure or composite) with different loading ratios were tested for their relative performance using chemical liquids as oxidants in the PEM fuel cell (reactor). The maximum electrical power obtained from a single layer of PEM fuel cell was 0.259 mW/cm². Experimental results are promising and the new coupling of chemical reactions may be used successfully in the electrochemical reactor (fuel cell) to tap solar energy to generate power. Further work is needed to put this concept into reality for power generation from a solar assisted PEM fuel cell system.