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Synthesis of 9-Fluorenemethyl Boranophosphonodiphosphate Via an H-Phosphonate Approach
Authors:
Hongyan Liu a;
Syed N. Hashmi a;
Barbara Ramsay Shaw a
| Affiliation: | a Department of Chemistry, Duke University, Durham, North Carolina, USA |
DOI:
10.1080/15257770701542413
Publication Frequency:
12 issues per year
Published in:
Nucleosides, Nucleotides and Nucleic Acids,
Volume
26,
Issue
10 -
12
October
2007
, pages 1455
- 1457
Nucleosides, Nucleotides and Nucleic Acids,
Volume
26,
Issue
10 -
12
October
2007
, pages 1455
- 1457
Subjects:
Drug Design & Development;
Medicinal & Pharmaceutical Chemistry;
Organic Chemistry;
Pharmaceutical Science;
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Abstract
9-Fluorenemethyl boranophosphonate 6 and its boranophosphonodiphosphate 7 were synthesized via an H-phosphonate approach. The method is efficient for the synthesis of acyclic compounds 6 & 7, and can be explored for the synthesis of nucleoside 5'-deoxy boranophosphonodiphosphate.
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| Keywords: Boranophosphonate; boranophosphonodiphosphate; antiviral; H-phosphonate; triphosphate analogues |
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