This methodological paper addresses practical strategies, implications, benefits and drawbacks of collecting qualitative semi-structured interview data about Internet-based research topics using four different interaction systems: face to face; telephone; email; and instant messaging. The discussion presented here is based on a review of the literature and reflection on the experiences of the authors in performing completed research that used those four interaction systems. The focus is on functional effects (e.g. scheduling and other logistics, data transcription and data management), as well as methodological effects (e.g. ability to probe, collecting affective data, and data representation). The authors found that all four methods of data collection produced viable data for the projects they completed, but that some additional issues arose. Five themes emerged that form the organization of the paper: (1) interview scheduling and participant retention; (2) recording and transcribing; (3) data cleaning and organizing; (4) presentation and representation of data; and (5) the detection/presentation of affective data.