This paper presents a single instruction multiple data tabu search (SIMD-TS) algorithm for the quadratic assignment problem (QAP) with graphics hardware acceleration. The QAP is a classical combinatorial optimisation problem that is difficult to solve optimally for even small problems with over 30 items. By using graphic hardware acceleration, the developed SIMD-TS algorithm executes 20 to 45 times faster than traditional CPU code. The computational improvement is made possible by the utilisation of the parallel computing capability of a graphics processing unit (GPU). The speed and effectiveness of this algorithm are demonstrated on QAP library problems. The main contribution of this paper is a fast and effective SIMD-TS algorithm capable of producing results for large QAPs on a desktop personal computer equivalent to the results achieved with a CPU cluster.