Solid rocket motors (SRMs) and liquid rocket engines (LREs) deplete the global ozone layer in various capacities. We estimate global ozone depletion from rockets as a function of payload launch rate and relative mix of SRM and LRE rocket emissions. Currently, global rocket launches deplete the ozone layer ∼0.03%, an insignificant fraction of the depletion caused by other ozone depletion substances (ODSs). As the space industry grows and ODSs fade from the stratosphere, ozone depletion from rockets could become significant. This raises the possibility of regulation of space launch systems in the name of ozone protection. Large uncertainties in our understanding of ozone loss caused by rocket engines leave open the possibility that launch systems might be limited to as little as several tens of kilotons per year, comparable to the launch requirements of proposed space systems such as spaceplanes, space solar power, and space reflectors to mitigate climate change. The potential for limitations on launch systems due to idiosyncratic regulation to protect the ozone layer present a risk to space industrial development. The risk is particularly acute with regard to the economic rationale to develop low-cost, high flight rate launch systems.