Objective: To document the pattern of and ability of sickle cell anemic patients to manage painful crises at home. Subject and methods: Confirmed HbSS patients or caregivers attending the University of Nigeria Teaching Hospital (UNTH), Enugu, Nigeria, were interviewed, using a questionnaire, on their last painful episode. Results: The limbs were involved in all ages, but involvement of the joints, ribs, and spine was uncommon in patients under 5 years old. Pain started between 6 pm and 12 midnight in 33.3%. Analgesics with or without massage or hydration was mostly used at home. 29% of subjects required hospitalization. Conclusion: Patients need better access to more potent analgesics to reduce the burden on the health system.