We hypothesized that gratitude would be related to sense of coherence via positive reframing, which is a process by which negative events or circumstances are seen in a positive light. We tested this hypothesis in two studies. In Study 1 (N = 166) we found a strong, robust relationship between trait gratitude and sense of coherence above and beyond life satisfaction, positive and negative affect, happiness, and social desirability. Study 2 (N = 275) showed that gratitude at Time 1 predicted sense of coherence at Time 2, controlling for baseline scores. Positive reframing mediated the relationship between gratitude and SOC. Results are discussed in terms of their practical implications.