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On testing the proportionality of two cumulative incidence functions in a competing risks setup 

Authors: Jean-Yves Dauxois a; Syed N. U. A. Kirmani b
Affiliations:   a CREST-ENSAI, Bruz, France
b Department of Mathematics, University of Northern Iowa, Cedar Falls, Iowa, USA
DOI: 10.1080/10485250310001622866
Publication Frequency: 8 issues per year
Published in: journal Journal of Nonparametric Statistics, Volume 16, Issue 3 & 4 June 2004 , pages 479 - 491
Number of References: 47
Formats available: HTML (English) : PDF (English)
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Abstract

A large sample test of proportionality of two cumulative incidence functions is developed for randomly right censored competing risks data without assuming that the K ≥ 2 risks are independent. The test is tailored to detecting monotonicity of the ratio of the two cumulative incidence functions and the test statistic is proved to be asymptotically normally distributed. In addition, it is shown that the proposed test can be readily adapted to test whether the censoring random variable and observable survival time have proportional hazards. The procedures are illustrated through application to two data sets well known in the survival analysis literature.
Keywords: Aalen-Johansen estimator; Absolute cause-specific risk; Asymptotic normality; Crude incidence curve; Koziol-Green model; Random right-censoring; Retro-hazard; Total positivity of order 2
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