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Blastic mantle cell lymphoma with a Burkitt translocation 

Authors: Kavita Reddy a;  Mohammad Ansari-Lari b; Bruno Dipasquale c
Affiliations:   a Genzyme Genetics, NY, USA
b Department of Pathology, Memorial Regional Hospital, FL, USA
c Department of Pathology, Physicians Regional Medical Center, FL, USA
DOI: 10.1080/10428190701852024
Publication Frequency: 12 issues per year
Published in: journal Leukemia and Lymphoma, Volume 49, Issue 4 April 2008 , pages 740 - 750
First Published: April 2008
Formats available: HTML (English) : PDF (English)
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Abstract

MYC gene rearrangements are observed as a genetic change in the blastoid variant of mantle cell lymphoma (MCL). We present two patients, one had 30% atypical lymphocytes with Burkitt-like morphology in the peripheral blood and the other had 30% blasts in the bone marrow. Both had a CCND1/IGH and an MYC rearrangement by cytogenetics and FISH. The immunophenotype was CD5+[one was a weak positive], CD10+, CD20+, CCND1+, >90% Ki-67 proliferation fraction and CD23 negative. The diagnosis was blastic MCL with Burkitt features. These cases, along with the reported cases, distinguish an aggressive category of a blastic MCL with a poor prognosis that probably requires Burkitt therapy.
Keywords: CCND1/IGH; MYC; aggressive blastoid MCL; molecular cytogenetics; neoplasia; chemotherapeutic approaches
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