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Multiple steady state profiles in interconnected biological systems

Authors: A. K. Drameacute a;  J. Harmand b;  A. Rapaport a; C. Lobry c
Affiliations:   a UMR Analyse des Systegravemes et Biomeacutetrie, INRA, Montpellier, France
b Lab. de Biotechnologie de l'Environnement, INRA, Narbonne, France
c INRIA Sophia-Antipolis, Sophia-Antipolis
DOI: 10.1080/13873950600723277
Publication Frequency: 6 issues per year
Published in: journal Mathematical and Computer Modelling of Dynamical Systems, Volume 12, Issue 5 October 2006 , pages 379 - 393
Formats available: HTML (English) : PDF (English)
Previously published as: Mathematical Modelling of Systems (1381-2424) until 1998
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Abstract

This paper deals with a generic approach for the analysis of interconnected biological systems. The equilibrium points as well as the asymptotic behaviour of these systems are investigated from a qualitative point of view. In particular, a new generic approach is used to show that a series of Continuously Stirred Tank Reactors (CSTRs) can exhibit multiple steady state profiles, for any non-monotonic kinetics. This multiplicity property disappears when the number of reactors becomes sufficiently large (for a given total volume). These results are to be taken in account when CSTRs in series are used to approximate a Piston Flow Reactor (PFR).
Keywords: Biological systems; Multiple steady states; Interconnected systems; Convergence; Substrate inhibited kinetics
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