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Stochastic analysis of autoregulatory gene expression dynamics

Authors: T. Ochiai a; J. C. Nacher b
Affiliations:   a Faculty of Engineering, Toyama Prefectural University, Toyama, Japan
b Department of Complex Systems, Future University-Hakodate, Hokkaido, Japan
DOI: 10.1080/13873950801972186
Publication Frequency: 6 issues per year
Published in: journal Mathematical and Computer Modelling of Dynamical Systems, Volume 14, Issue 4 August 2008 , pages 377 - 388
First Published: August 2008
Formats available: HTML (English) : PDF (English)
Previously published as: Mathematical Modelling of Systems (1381-2424) until 1998
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Abstract

In this work, the autoregulatory genetic module is investigated by using stochastic theory. We show here that the stochastic effect of the second order perturbation theory further reduces the fluctuation size of the gene expression level more than what is expected in deterministic methods. Furthermore, dynamical aspects of the system were investigated. In particular, we estimated the time needed to reach the equilibrium state.
Keywords: autoregulatory genetic module; stochastic theory; noise; Fokker-Planck equation
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