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Androgens: Biphasic Dose Responses 

Author: Edward J. Calabrese a
Affiliation:   a Department of Environmental Health Sciences, School of Public Health and Health Sciences, University of Massachusetts, Amherst, MA 01003 USA. Tel: 413-545-3164. Fax: 413-545-4692. email: edwardc@schoolph.umass.edu.
DOI: 10.1080/20014091111794
Publication Frequency: 10 issues per year
Published in: journal Critical Reviews in Toxicology, Volume 31, Issue 4 & 5 July 2001 , pages 517 - 522
Subject: Toxicology;
Formats available: PDF (English)
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Abstract

Testosterone was reported to affect a variety of reproductive endpoints. More notable were the effects of dihydrotestosterone on cell proliferation in the prostate cancer cell model LNCaP and Sertoli cell function. Testosterone production was also biphasically affected by prolactin that was administered to adult testicular cells in vitro.
Keywords: testosterone; androgen; hormesis; U shaped; biphasic; stimulatory; inhibitory; dose response; receptor mediated
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