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Multidrug resistance proteins and topoisomerase II
expression in colon cancer: association with metastatic potential
Authors:
Haralampos S. Zorzos a;
Andreas C. Lazaris a;
Penelope A. Korkolopoulou a;
Nikolaos G. Kavantzas a;
Sofia Tseleni-Balafouta a;
Efstratios S. Patsouris a;
Nikolaos V. Tsavaris a;
Panagiotis S. Davaris a
| Affiliation: | a Department of Pathology, School of Medicine, National and Capodistrian University of Athens, Greece |
DOI:
10.1080/0031302031000150524
Publication Frequency:
7 issues per year
Subject:
Pathology;
Number of References: 21
Formats available:
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(English)
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Abstract
Aims: To investigate the role of multidrug resistance proteins and topoisomerase II
 in colon cancer. Methods: Tissue sections from 89 Dukes' stage B-D colon cancer patients were selected. The expression of multidrug resistance proteins and topoisomerase II in primary tumour cells was assessed by standard immunohistochemistry. The extent of their expression was measured by image analysis and was correlated with clinicopathological features of the patients. Results: P-glycoprotein was associated with the presence of lymph node metastasis (P=0.005), vessel invasion (P=0.0001) and perineural invasion (P=0.020). Conclusions: P-glycoprotein is probably involved in the processes of local invasion and metastatic dissemination. |
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Keywords:
P-glycoprotein;
Topoisomerase II;
colon cancer;
chemotherapy
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