Transfer function models for the description of physical systems have recently been introduced. They provide an alternative to the conventional representation by partial differential equations (PDE) and are suitable for computer implementation. This paper presents transfer function modelling for vector PDEs. They arise from the physical analysis of multidimensional systems in terms of potential and flux quantities. Expressing the resulting coupled PDEs in vector form facilitates the direct formulation of boundary and interface conditions in their physical context. It is shown how a carefully constructed transformation for the space variable leads to transfer function models for vector PDEs. They are the starting point for the derivation of discrete models by standard methods for one-dimensional systems. The presented functional transformation approach is suitable for a number of technical applications, like electromagnetics, optics, acoustics and heat and mass transfer. Examples are given for the voltage and current distribution on an electrical transmission line and the velocity and force distribution on longitudinal vibrating strings.