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Accelerated radiotherapy for advanced laryngeal cancer 

Authors: Hedda Haugen a;  Karl-Axel Johansson b;  Hasse Ejnell c;  Staffan Edstroumlm c; Claes Mercke a
Affiliations:   a Department of Oncology, Sahlgrenska University Hospital, Goumlteborg, Sweden
b Department of Radiophysics, Sahlgrenska University Hospital, Goumlteborg, Sweden
c Department of Oto-Rhino-Laryngology, Sahlgrenska University Hospital, Goumlteborg, Sweden
DOI: 10.1080/02841860510029950
Publication Frequency: 8 issues per year
Published in: journal Acta Oncologica, Volume 44, Issue 5 July 2005 , pages 481 - 489
Subject: Oncology;
Formats available: HTML (English) : PDF (English)
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Abstract

The purpose of this study was to evaluate a single institution's outcome for patients with advanced laryngeal cancer treated with accelerated radiotherapy (RT). Fifty-eight patients with advanced laryngeal cancer (T3/T4N0/N + M0) were treated with curative intent with accelerated RT during the period 1990 - 1998. Patients received radiotherapy alone or with induction chemotherapy. The 5-year local control (LC) and loco-regional control (LRC) probabilities were both 49% for T3 and 75% for T4 tumors. The 5-year disease-free survival probability was 46% and 68% and overall survival probability was 30% and 39% for T3 and T4 tumors respectively. No significant statistical difference in outcome was found, either between T3 and T4 tumors, or between patients who received induction chemotherapy and those who did not. The treatment results for advanced laryngeal cancer at this institution were comparable to those reported in the literature. The results for T3 and T4 were similar. T4 classification alone should not be an exclusion criterion for larynx preservation. Overall survival was poor, partly because of a high incidence of deaths from intercurrent diseases.
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