Efficient Synthesis of 2'-Amino-2'-deoxypyrimidine 5'-Triphosphates

Authors: Danny P. C. McGee ^a; Chandra Vargeese ^a; Yansheng Zhai ^a; Gary P. Kirschenheuter ^a; Alecia Settle ^a; Colleen R. Siedem ^a; Wolfgang A. Pieken ^a

Affiliation:

^a NeXagen Inc., Boulder, CO, USA

DOI: 10.1080/15257779508010694

Publication Frequency: 12 issues per year

Published in: journal

Nucleosides, Nucleotides and Nucleic Acids, Volume 14, Issue 6 August 1995 , pages 1329 - 1339

Subjects: Drug Design & Development; Medicinal & Pharmaceutical Chemistry; Organic Chemistry; Pharmaceutical Science;

Formats available: PDF (English)

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Abstract

The synthesis of 2'-amino-2'-deoxypyrimidine 5'-triphosphates is described. The 2'-amino-2'-deoxyuridine 5'-triphosphate is obtained from uridine in four steps with 25% overall yield. The 2'-amino-2'-deoxycytidine 5'-triphosphate is obtained from uridine in seven steps with 13% overall yield.

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Efficient Synthesis of 2'-Amino-2'-deoxypyrimidine 5'-Triphosphates

Abstract