Curculigo orchioides Gaertn. (Hypoxidaceae) is known as “talamuli” or “musali” in Ayurveda and as “nilapanai” in Siddha. The root tuber is used in the treatment of diabetes and several other diseases. Both alcohol and aqueous extracts were tested with alloxan-induced diabetic rats. Blood glucose levels were evaluated on the 7th, 14th, and 21st days. Doses of 500 and 1000 mg/kg body weight of both extracts produced significant (p < 0.001) hypoglycemic activity in alloxanized rats when compared with diabetic control.