The two main objectives of this study were to measure and analyse initial learning rates and electromyographic activity while using the Kinesis Ergonomic Computer Keyboard. Six professional typists learned how to use the Kinesis Ergonomic Computer Keyboard. After an initial learning period electromyographic activity in four muscles in the forearms was recorded while typing on the Kinesis Ergonomic Computer Keyboard. These data were then compared to electromyographic activity recorded while using a standard 101 key IBM PS/2 keyboard. The study showed that the Kinesis Ergonomic Computer Keyboard can be learned to 72% of speed proficiency of the standard keyboard within 115 minutes. An accuracy of 97% of the standard keyboard was reached within 65 minutes of use. After the initial learning period, subjects were able to relearn quickly to use the Kinesis Ergonomic Computer Keyboard after a break of several weeks. Electromyographic data analysis showed that the resting posture on the Kinesis Ergonomic Computer Keyboard required significantly less activity to maintain than the resting posture on the standard keyboard for the flexor carpi ulnaris and the flexor digitorum sublimis. Furthermore, the Kinesis Ergonomic Computer Keyboard reduced the muscular activity required for typing in the flexor carpi ulnaris, the extensor digitorum communis, and the flexor digitorum sublimis.