Statements produced by the Regulatory Authorities have impacted significantly on the practice of Menopausal Medicine. The advice that the lowest dose of hormone therapy should be given for the shortest possible time and that hormone therapy should no longer be a first-line treatment for osteoporosis has lead to a major shift in prescribing practice. Since these statements have such an enormous impact, this presentation will consider further the background to the authorities and the mechanism by which their decisions were reached.