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Pharmacokinetics of Intravenously Administered Desmosine in Sheep
Authors:
Pritam S. Verma a;
Robert F. Hoyt Jr. a;
Andre J. Jackson b;
Yancy Y. Phillips a
| Affiliations: | a Department of Clinical Physiology, Walter Reed Army Institute of Research, Washington, DC |
| b School of Pharmacy, University of Maryland, Baltimore, MD |
DOI:
10.3109/03008208409013681
Publication Frequency:
6 issues per year
Subjects:
Cell Biology;
Molecular Biology;
Formats available:
PDF
(English)
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Abstract
The pharmacokinetics of desmosine following a 5 mg intravenous dose was determined in five sheep. The biological half-life (t1/2 β) of desmosine varied between 81-489 min. Urinary recovery of unchanged desmosine indicated that the compound is not extensively metabolized and that the primary route of elimination is via the kidney.
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