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Toxic Neonatal Effects Following Maternal Clomipramine Therapy
Authors:
Michael S. Schimmell a;
Ester Zylber Katz b;
Yechezkel Shaag a;
Anne Pastuszak c;
Gideon Koren cd
| Affiliations: | a Department of Neonatology, Shaare Zedek Medical Center, Jerusalem, Israel |
| b Clinical Pharmacology Unit, Hadassah University Hospital, Jerusalem, Israel | |
| c Motherisk Program, Division of Clinical Pharmacology, The Hospital for Sick Children, Toronto, Canada | |
| d The Hospital for Sick Children, Toronto, Ontario, Canada |
DOI:
10.3109/15563659109025744
Publication Frequency:
10 issues per year
Subject:
Clinical Toxicology;
Formats available:
PDF
(English)
Previously published as:
Journal of Toxicology: Clinical Toxicology
(0731-3810)
until 2005
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Abstract
Clomipramine is a chlorinated tricyclic antidepressant commonly used in the treatment of depression (1). The drug is widely prescribed in Europe and Canada and has been recently approved for use in the USA. Its safety during pregnancy and breastfeeding, however, has not been fully established. Very few reports on its effect on the fetus and neonate have been published (2,3).
We report a case of a mother treated with clomipramine during pregnancy, and the side effects observed in the infant. The correlation between plasma clomipramine concentrations in the baby's blood and clinical effects are described. Subsequently, we present the pregnancy outcome of five prospectively collected cases. |
| Keywords: tricyclic antidepressant; clomipramine; in utero toxicity; pregnancy; milk; human |
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