One hundred patients with chronic arthritis were interviewed and completed questionnaires about coping, well-being and their use of humour. A comparison of patients scoring high or low on each of 3 measures of humour showed that those who reported they used humour least, had most difficulty recognising it and valued it least. They also reported more depressive symptoms and lower personal self-esteem. Regressions showed that depression was best predicted by the inactive use of humour in coping. and to a lesser extent, pain intensity. Cluster analysis of data on general coping strategies showed that valuing humour distinguished two-thirds of patients who were relatively normal and cautiously optimistic, from the other third, where the outlook was negative and hopeless. Those with a more positive view tended to be younger, less disabled, in less pain and with several social advantages on a number of indicators. However they also had a longer duration of disease. Two-thirds of patients said they were able to laugh when in pain but those most able to do this had less intense pain during the previous week. Furthermore the most disabled arthritis patients found laughter to be a most effective strategy. The research has implications for preventing depression and coping with disability.