In the four years since the first MedlinePlus Go Local site, NC Health Info, was launched in January 2003, more than two dozen Go Local projects have sprung up to link MedlinePlus visitors to health-related services in their own local areas.¹ Each Go Local site reflects its own region's special characteristics and the choices made during its development. This article describes those characteristics and choices for Lone Star Go Local <http://golocal.uthscsa.edu>, the Go Local site for South Texas, tracing the background, circumstances and decisions that shaped it, and providing insights for other libraries and consortia planning Go Local projects of their own.