In April 2004, Health InfoNet of Alabama became one of the first consumer health services in the country to take part in the National Library of Medicine's MedlinePlus Go Local initiative. The availability of technical support was a primary factor in Health InfoNet's decision to participate as an NLM-hosted site rather than revise its existing Web site to meet Go Local standards. This decision meant tradeoffs concerning the service offerings of Health InfoNet, which led to the question, “What guided other project directors' decisions to participate in Go Local either via locally hosted or NLM-hosted sites?” The study's purpose was to get an impression of the various issues surrounding the choices made by Go Local participants pertaining to their choice of Web site hosting environments, with special emphasis placed on the organizational motivation, impact, and satisfaction precipitated by this decision. The paper's objective is to examine the NLM Go Local initiative in the context of evolving consumer health Web sites and to develop issues for future Go Local participants to consider, including those involving collection development of online consumer health resources. doi:10.1300/J381v11n02_04