| Volume 18 Number 2/3 December 1999 Papers
Managing genetic testing: the relative powerlessness of actors in stable practices
Annemiek Nelis 125 Whose DNA? Genetic surveillance, ownership of information and newborn screening
Margaret Boyes 145 Actor networks, international political economy and risk in genetic manipulation
Alan Russell 157 special topic: xenotransplantation
Debates in xenotransplantation: on the consequences of contradiction
Nik Brown 181 Xenotransplantation, risk, regulation and surveillance: social and technological dimensions of change
Ian Welsh & Robert Evans 197 Notes and Issues
Editorial Introduction
The Editors The framework for overseeing developments in biotechnology: forthcoming changes
Office of Science and Technology 219 Book Reviews
Biotechnology in the Public Sphere: A European Sourcebook (edited by John Durant, Martin W. Bauer & George Gaskell) 227 Enhancing Human Traits: Ethical and Social Implications (edited by Erik Parens) 229 Genetic Imaginations: Ethical, Legal and Social Issues in Human Genome Research (edited by P. Glasner & H. Rothman); The Social Management of Genetic Engineering (edited by P. Wheale, R. von Schomberg & P. Glasner) 231 Governing Molecules: The Discursive Politics of Genetic Engineering in Europe and the United States (by Herbert Gottweis) 233 Brave New Worlds: Genetics and Human Experience (by Brian Appleyard) 234 Human DNA: Law and Policy, International and Comparative Perspectives
(edited by Bartha Maria Knoppers, Claude M. Laberge & Marie Hirtle) 236 Index, Volume 18 237 Volume 18 Number 1 April 1999 Editorial
Peter Glasner & Harry Rothman 5 Papers
Cloning humans, cloning literature: genetics and the imagination deficit
Jos Van Dijck 9 The social management of modern biotechnology and the new industrial divide
Peter Wheale 23 Britain's biotechnology controversy: elusive science, contested expertise
Les Levidow 47 Dealing with the risks of genetic engineering as an example of 'reflexive modernization'?
Wolfgang van den daele 65 Experiments in the governance of biotechnology: a case study of the UK National Consensus Conference
Derrick Purdue 79 Knowledge about genes and heredity among Finns
Piia Jallinoja & Arja R. Aro 101 Review Essay
What we know and what we don't about cloning and society
Sarah Franklin 111 New Genetics and Society
(Formerly The Genetic Engineer and Biotechnologist) FORTHCOMING PAPERS John Durrant on European public perceptions of human genetics Wolfgang van den Daele on risk regulation, genetic engineering, and reflexive modernisation Sheldon Krimsky on altering the gene pool and moral defensibility Pat Spallone & Tom Wilkie on cloning, the public, and evidence-based ethics Peter Wheale on why modern genetic engineering needs social managing Sir Colin Campbell on the policy role of the UK Advisory Commission on Human Genetics VOLUME 17 NUMBER 4 DECEMBER 1997 EDITORIAL
Calling It a Day Caroline MacDonald 155 PAPERS
Enzymatic Determination of D-Glucose in Cell Culture Media Using Glucose Oxidase, Horseradish Peroxidase and 3,3´ ,5,5´-Tetramethylbenzidine
Martin Schr der & Peter Friedl 157 Anaerobic Treatment of Potato-Starch Wastewater Using a Foam Bed Bioreactor
B. N. Mishra & Anil Kumar 165 Effects on Processing and Antigenicity of Linking the Pk Epitope Tag to the N or C Terminus of the HN Protein of the Paramyxovirus, SV5 M. O'Reilly &
R. E. Randall 175 REVIEW
Starch Phosphorylase: Biochemical, Molecular and Biotechnological Aspects
Sadhana A. Nighojkar & Anil Kumar 189 Book reviews 203 Index, Volume 17 215 VOLUME 17 NUMBERS 2&3 SEPTEMBER 1997 EDITORIAL
ESACT UK (1997) Alan Dickson 67 PAPERS
Real-time Monitoring of Recombinant Protein Concentration in Animal Cell Cultures Using an Optical Biosensor Kym Baker, Andrew Ison, Robert Freedman, Walis Jones & David James 69 The Effect of Hyperosmotic Conditions on Growth and Recombinant Protein Expression by NS0 Myeloma Cells in Culture Philippa J. Duncan, Helen A. Jenkins & Glyn Hobbs 75 A Novel Method for Determining Cell Strength:Description and Applications in Animal Cell Technology D. C. Edwards, D. R. Lloyd & M. Al-Rubeai 79 Non-viral Gene Therapy Using Purified Plasmid DNA Condensed with Cationic Peptides of Defined Structure Julian A. J. Hanak 83 A Flow Cytometric Assay to Monitor Apoptosis in Cell Culture Using a pH-sensitive Fluoroprobe Carboxy SNARF-1-AM A. Ishaque, R. P. Singh & M. Al-Rubeai 85 Expression of Cytochrome P450 Isoforms in Immortalised Rat Hepatocyte Cell Lines
H. T. Kelly, K. Anderson, L. Hill, M. H. Grant & C. MacDonald 89 Role of Cell Cycle and Culture Conditions in Determining Specific and Total
Interferon-g Productivity of CHO Cells V. Leelavatcharamas, D. R. Lloyd, A. N. Emery
& M. Al-Rubeai 93 A Rapid Flow Cytometric Method for the Determination of Cell Number and Viability in Animal Cell Technology D. R. Lloyd, K. Welzenbach, A. N. Emery & M. Al-Rubeai 97 The Semliki Forest Virus System:Receptor Expression and Scale-up Kenneth Lundstrom, Horst Blasey, Ruud Hovius, Horst Vogel & Alain Bernard 101 Immortalised Hepatocytes as Alternatives to the Use of Animals T. Maguire, H. J. Moulsdale, C. Touchard & G. N. Stacey 107 Large-scale Free Suspension Animal Cell Culture: Cell Fragility versus Media Homogeneity A. W. Nienow 111 The Endoplasmic Reticulum Proteins, GRP78 and GRP94, Associate with Both H and L Immunoglobulin Subunits in a Recombinant Myeloma Cell Line Alison Pearce & Helen A. Jenkins 115 Influence of Culture Media Compounds on Cell Death in CHO Cell Lines A. Perani, R. P. Singh & M. Al-Rubeai 117 Essential Amino Acid Deprivation of Hybridoma Cells Results in the Induction of High Levels of Apoptosis, Which Is Suppressed by bc1-2 Over-expression
R. P. Singh, N. H. Simpson, A. Perani, C. Goldenzon & M. Al-Rubeai 121 pH: Effects on Growth and Productivity of Cell Lines Producing Monoclonal Antibodies: Control in Large-scale Fermenters J. Wayte, R. Boraston, H. Bland, J. Varley & M. Brown 125 Book Reviews 133 Calendar 147 VOLUME 17 NUMBER 1 MARCH 1997 EDITORIAL
Hello Dolly Caroline MacDonald 3 PAPER
A Biofilm Model for Fixed-bed Anaerobic Reactors: Performance Analysis Considering Diffusional Resistances and Axial Dispersion B. N. Mishra, S.P. Singh & Anil Kumar 5 REVIEW
Structure and Function of Growth Factors Dajiang Li, Simon Hettle, Jong McLean & Caroline MacDonald 23 Book Reviews 47 News 57 Calendar 61 VOLUME 16 NUMBER 4 DECEMBER 1996 EDITORIAL
Commercialising Biotechnology Caroline MacDonald 203 CONFERENCE REPORTS
BioInnovations '96, 24-26 September, Wembley Conference Centre, London
Gordon F. Bickerstaff 205 Report on the 6th Meeting of ESACT-UK, 4-5 January 1996, Leeds Barrie Rooney 209 PAPER
Indirect Sandwich ELISA for Human Antithrombin III Employing the Interaction Between D-Biotin and Streptavidin Martin Schrder, Dirk Kaiser, Rolf Sch fer & Peter Friedl 211 REVIEW
Apoptosis: Exploiting Novel Pathways to the Improvement of Cell Culture Processes Rabinder P. Singh, Mohamed Al-Rubeai & A. Nicholas Emery 227 Book Reviews 253 Calendar 263 Index, Volume 16 269
VOLUME 16 NUMBER 3 SEPTEMBER 1996 EDITORIAL
Biotechnology in Europe Caroline MacDonald 131 PAPERS
The Role of Eukaryotic Initiation Factor-2 in the Control of Protein Synthesis in Murine Erythroleukaemia Cells Justine E. Hyde & Helen A. Jenkins 133 Compartmentation of the Protein Synthetic Machinery of CHO Cells into Free, Cytoskeletal-bound and Membrane-bound Polysomes Ian F. Pryme, Kris Partridge, Arild J. Johannessen, Diego Jodar, Albert Tauler & John E. Hesketh 137 Immobilisation of Starch Phosphorylase from Bengal Gram Seeds: Production of Glucose-1-phosphate Seema Pavgi-Upadhye & Anil Kumar 145 REVIEWS
Biotechnology in Japan Meredith Lloyd-Evans 153 Influences of Substrate Chemistry and Microbial Metabolic Diversity on the Bioremediation of Xenobiotic Contamination E. S. B. Limbert & W. B. Betts 159 Book Reviews 181 Calendar 195 VOLUME 16 NUMBER 2 JUNE 1996 EDITORIAL
Patent or Be Damned? Caroline MacDonald 67 CONFERENCE REPORT
Report on the JAACT '95 Conference, Fukuoka, Japan Andrew Hooker & Pauline Kemp 69 PAPER
Demethoxylation of Pectin Using Immobilised Cuscuta reflexa Pectin Methylesterase Sadhana Srivastava, Anand Nighojkar & Anil Kumar 73 REVIEWS
Gene Transfer into Mammalian Cells: The Road to Human Gene Therapy Walter H. G nzberg & Brian Salmons 81 Europe Is Important to US Biotechnology Companies Alan Williams 99 Book Reviews 109 News 119 Calendar 125 VOLUME 16 NUMBER 1 MARCH 1996 EDITORIAL
Assessing the Quality of Research-A Challenge Indeed Carolina MacDonald 3 CONFERENCE REPORT
Tripartite Meeting on Comparative Medicine Section of the Royal Society of Medicine, the Veterinary Research Group and the Southern Region of the Association of Veterinary Teachers and Research Workers, 7 June 1995, University of Cambridge Meredith Lloyd-Evans 5 PAPERS
Induction of a -Interferon Production from Namalwa Cells Grown in Protein-free Medium and Potentiation of Induction by Insulin Michael J. Keen, Dawn Halton & Carolyn L. Dent 9 Characterisation of Genetic Control of Thermotolerance in Mutants of Saccharomyces cerevisiae Leela Wati, S. S. Dhamija, Dalel Singh, Poonam Nigam & Roger Marchant 19 Electroporation Conditions for Retention of Rat Hepatocyte Viability Li Yin, Caroline MacDonald & Helen Grant 27 SHORT REPORT
SELA/EU Bridge Project on Biotechnology: Cooperation for Development Alberto Diaz & Antonio Leone 35 Book Reviews 39 News 49 Calendar 55 VOLUME 15 NUMBER 2&3 1995 EDITORIAL
Changes in Editorial Policy Caroline MacDonald 67 I. VARIA
Some Questions and Answers on the Need for Chartered Status for Biotechnologists R. E. Spier 69 Solvent-free System for Interesterification of Palm Oil Fractions by Immobilised Lipase Wan Hasamudin W. Hassan, Sabariah Samsudin, Rosnah M. Soom, Mohamadiah Banjari, Wan Zailan W. Omar & John F. Kennedy 77 II. WORKSHOP ON SOCIAL, POLITICAL & ETHICAL ISSUES IN HUMAN GENOME RESEARCH
Social Dimensions of the Human Genome Mapping Project: An Introduction
Peter Glasner & Harry Rothman 85 Transitional Science and the Human Genome Mapping Project Resource Centre
Brian Balmer 89 How Weak Bonds Stick? Genetic Diagnosis Between the Laboratory and the Clinic
Jean-Paul Gaudilli re 99 Information Technology as an Instrument of Genetics Christine Hine 113 Exploring Organisational Issues in British Genomic Research Peter Glasner, Harry Rothman & David Travis 125 Eugenics Here and Now
Ruth McNally 135 Moral and Legal Consequences for the Fetus/Unborn Child of Medical Technologies Derived from Human Genome Research Peter R. Wheale 145 The American Gene Therapy Industry and the Social Shaping of a New Technology
Paul Martin 155 Social Criticism and the Human Genome Programme: Some Reflections on the Limits of a Limited Social Science Hilary Rose 169 Signs of Life—Taking Genetic Literacy Seriously Jon Turney 181 Book Reviews 189 Calendar 203
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