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Volume 37 Issue 8
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Reprints
Xenobiotica
The fate and safety evaluation of foreign compounds in biological systems
, Volume
37
Issue 8 2007
ISSN:
1366-5928 (electronic) 0049-8254 (paper)
Publication Frequency:
12 issues per year
Subjects:
Pharmacology
;
Toxicology
;
Publisher:
Informa Healthcare
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Original Articles
In vitro
metabolism of eupatilin by multiple cytochrome P450 and UDP-glucuronosyltransferase enzymes
H. S. Lee; H. Y. Ji; E. J. Park; S. Y. Kim
Pages 803 – 817
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Functional involvement of organic cation transporter1 (OCT1/Oct1) in the hepatic uptake of organic cations in humans and rats
K.-I. Umehara; T. Iwatsubo; K. Noguchi; H. Kamimura
Pages 818 – 831
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The metabolism of the 5HT
3
antagonists ondansetron, alosetron and GR87442 I: A comparison of
in vitro
and
in vivo
metabolism and
in vitro
enzyme kinetics in rat, dog and human hepatocytes, microsomes and recombinant human enzymes
G. I. Somers; A. J. Harris; M. K. Bayliss; J. B. Houston
Pages 832 – 854
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The metabolism of the 5HT
3
antagonists, ondansetron, alosetron and GR87442 II: Investigation into the
in vitro
methods used to predict the
in vivo
hepatic clearance of ondansetron, alosetron and GR87442 in the rat, dog and human
G. I. Somers; M. K. Bayliss; J. B. Houston
Pages 855 – 869
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Use of Freund's Complete Adjuvant (FCA) in inflammatory pain models: Consequences on the metabolism and pharmacokinetics of the non-peptidic delta receptor agonist SNC80 in the rat
D. Projean; E. Lessard; M. P. Ducharme; J. Ducharme
Pages 870 – 883
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Disposition and metabolic fate of prasugrel in mice, rats, and dogs
R. L. Smith; T. A. Gillespie; T. J. Rash; A. Kurihara; N. A. Farid
Pages 884 – 901
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