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Xenobiotica The fate and safety evaluation of foreign compounds in biological systems, Volume 37 Issue 10 & 11 2007

Modelling and Simulation Approaches to in vitro–in vivo, Extrapolation of ADME Properties in Drug Development, Editor: Gordon Gibson, Guest Editor: Amin Rostami-Hodjegan

Xenobiotica is moving!

ISSN: 1366-5928 (electronic) 0049-8254 (paper)
Publication Frequency: 12 issues per year
Subjects: Pharmacology; Toxicology;
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Editorials
Editorial
Pages 1013 – 1014
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Original Articles
Intestinal permeability and its relevance for absorption and elimination
H. Lennernäs
Pages 1015 – 1051
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Modelling and simulation in drug absorption processes
A. Dokoumetzidis;  G. Valsami; P. Macheras
Pages 1052 – 1065
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In vitro–in vivo extrapolation of hepatic clearance: Biological tools, scaling factors, model assumptions and correct concentrations
O. Pelkonen; M. Turpeinen
Pages 1066 – 1089
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In vitro–in vivo extrapolation of hepatic clearance involving active uptake: Theoretical and experimental aspects
P. J. H. Webborn;  A. J. Parker;  R. L. Denton; R. J. Riley
Pages 1090 – 1109
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Kinetic determinants of hepatic clearance: Plasma protein binding and hepatic uptake
M. Baker; T. Parton
Pages 1110 – 1134
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Challenges for blood–brain barrier (BBB) screening
P. Jeffrey; S. G. Summerfield
Pages 1135 – 1151
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Future directions for drug transporter modelling
S. Ekins;  G. F. Ecker;  P. Chiba; P. W. Swaan
Pages 1152 – 1170
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Transporter-mediated uptake into cellular compartments
S. Oswald;  M. Grube;  W. Siegmund; H. K. Kroemer
Pages 1171 – 1195
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Induction of hepatic cytochrome P450 enzymes: methods, mechanisms, recommendations, and in vitro–in vivo correlations
N. J. Hewitt;  E. L. Lecluyse; S. S. Ferguson
Pages 1196 – 1224
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Mechanism-based inactivation of human cytochrome P450 enzymes: strategies for diagnosis and drug–drug interaction risk assessment
K. Venkatakrishnan;  R. S. Obach; A. Rostami-Hodjegan
Pages 1225 – 1256
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Comparison of different approaches to predict metabolic drug–drug interactions
H. J. Einolf
Pages 1257 – 1294
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Challenges and opportunities with modelling and simulation in drug discovery and drug development
T. Lavé;  N. Parrott;  H. P. Grimm;  A. Fleury; M. Reddy
Pages 1295 – 1310
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Design of population pharmacokinetic experiments using prior information
K. Ogungbenro; L. Aarons
Pages 1311 – 1330
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On the anticipation of the human dose in first-in-man trials from preclinical and prior clinical information in early drug development
P. J. Lowe;  Y. Hijazi;  O. Luttringer;  H. Yin;  R. Sarangapani; D. Howard
Pages 1331 – 1354
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