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Journal of Biopharmaceutical Statistics, Volume 17 Issue 6 2007

Now Listed with IF of 0.951 ©2009 Thomson Reuters, 2008 Journal Citiation Reports®
ISSN: 1520-5711 (electronic) 1054-3406 (paper)
Publication Frequency: 6 issues per year
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Editorials
Guest Editorial—Statistical Issues in Adaptive Design Methods in Clinical Trials
Vladimir Dragalin
Pages 955 – 956
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Original Articles
Adaptive Designs in Clinical Drug Development: Opportunities, Challenges, and Scope Reflections Following PhRMA's November 2006 Workshop
Michael Krams;  Carl-Fredrik Burman;  Vladimir Dragalin;  Brenda Gaydos;  Andrew P. Grieve;  Jose Pinheiro; Willi Maurer
Pages 957 – 964
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Innovative Approaches for Designing and Analyzing Adaptive Dose-Ranging Trials
Björn Bornkamp;  Frank Bretz;  Alex Dmitrienko;  Greg Enas;  Brenda Gaydos;  Chyi-Hung Hsu;  Franz König;  Michael Krams;  Qing Liu;  Beat Neuenschwander;  Tom Parke;  José Pinheiro;  Amit Roy;  Rick Sax; Frank Shen
Pages 965 – 995
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Discussion of the “White Paper of the PhRMA Working Group on Adaptive Dose-Ranging Designs”
A. P. Grieve
Pages 997 – 1004
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Discussion of the Paper “Adaptive Dose-Ranging Designs”
Carl-Fredrik Burman
Pages 1005 – 1011
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Discussion of the “White Paper of the PhRMA PISC Working Group on Adaptive Dose-Ranging Designs”
Sergei Leonov
Pages 1013 – 1014
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Discussion of the “White Paper of the PhRMA Working Group on Adaptive Dose-Ranging Designs”
Sue-Jane Wang
Pages 1015 – 1020
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Discussion of “The White Paper of the PhRMA Working Group on Adaptive Dose-Ranging Designs”
Robert Hemmings
Pages 1021 – 1027
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Miscellany
Rejoinder
Pages 1029 – 1032
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Original Articles
Flexible Design and Efficient Implementation of Adaptive Dose-Finding Studies
Christopher J. Weir;  David J. Spiegelhalter; Andrew P. Grieve
Pages 1033 – 1050
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Adaptive Designs for Dose-Finding Studies Based on Sigmoid Emax Model
Vladimir Dragalin;  Francis Hsuan; S. Krishna Padmanabhan
Pages 1051 – 1070
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Recent Developments in Adaptive Designs for Phase I/II Dose-Finding Studies
Sarah Zohar; Sylvie Chevret
Pages 1071 – 1083
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Dose Finding Designs for Continuous Responses and Binary Utility
Valerii V. Fedorov; Yuehui Wu
Pages 1085 – 1096
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Optimal Designs for Estimating the Interesting Part of a Dose-Effect Curve
Frank Miller;  Olivier Guilbaud; Holger Dette
Pages 1097 – 1115
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A Bayesian Approach for Dose-Escalation in a Phase I Clinical Trial Incorporating Pharmacodynamic Endpoints
John Whitehead;  Yinghui Zhou;  Lisa Hampson;  Edouard Ledent; Alvaro Pereira
Pages 1117 – 1129
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Guest-Editor's Note: “Statistical Issues in Adaptive Design Methods in Clinical Trials”
Annpey Pong
Pages 1133 – 1134
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Adaptive Seamless Designs: Selection and Prospective Testing of Hypotheses
Christopher Jennison; Bruce W. Turnbull
Pages 1135 – 1161
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Statistical Analysis for Two-Stage Seamless Design with Different Study Endpoints
Shein-Chung Chow;  Qingshu Lu; Siu-Keung Tse
Pages 1163 – 1176
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Seamless Phase II/III Combination Study Through Response Adaptive Randomization
Lin Wang; Lu Cui
Pages 1177 – 1187
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