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Xenobiotica The fate and safety evaluation of foreign compounds in biological systems, Volume 39 Issue 1 2009

Xenobiotica is moving!

ISSN: 1366-5928 (electronic) 0049-8254 (paper)
Publication Frequency: 12 issues per year
Subjects: Pharmacology; Toxicology;
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Research Article
Characterization of human cytochrome P450 enzymes involved in the biotransformation of eperisone
H. H. Yoo;  N. S. Kim;  J. Lee;  D. R. Sohn;  C. Jin; D. H. Kim
Pages 1 – 10
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Acetaminophen bioactivation by human cytochrome P450 enzymes and animal microsomes
J. E. Laine;  S. Auriola;  M. Pasanen; R. O. Juvonen
Pages 11 – 21
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Development of an optimized procedure for the preparation of rat intestinal microsomes: comparison of hepatic and intestinal microsomal cytochrome P450 enzyme activities in two rat strains
A. Bruyère;  X. Declèves;  F. Bouzom;  L. Proust;  M. Martinet;  B. Walther; Y. Parmentier
Pages 22 – 32
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Preclinical pharmacokinetics of MK-0974, an orally active calcitonin-gene related peptide (CGRP)-receptor antagonist, mechanism of dose dependency and species differences
S. Roller;  D. Cui;  C. Laspina;  C. Miller-Stein;  J. Rowe;  B. Wong; T. Prueksaritanont
Pages 33 – 45
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Absorption, distribution, metabolism and excretion (ADME) study with 2,2′,4,4′,5,6′-hexabromodiphenyl ether (BDE-154) in male Sprague–Dawley rats
H. Hakk;  J. K. Huwe; G. L. Larsen
Pages 46 – 56
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Presentation of a modified dispersion model (MDM) for hepatic drug extraction and a new methodology for the prediction of the rate-limiting step in hepatic metabolic clearance
U. Fagerholm
Pages 57 – 71
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Trans-resveratrol-mediated inhibition of β-oestradiol conjugation in MCF-7 cells stably expressing human sulfotransferases SULT1A1 or SULT1E1, and human liver microsomes
D. Ung; S. Nagar
Pages 72 – 79
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Mechanisms of action of two different natural mixtures of persistent organic pollutants (POPs) in ovarian follicles
E. L. Gregoraszczuk;  A. Ptak;  J. U. Skaare;  K. Mularz;  A. Chmielowiec;  A. Wojtowicz; E. Ropstad
Pages 80 – 89
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Statin-induced myopathy in the rat: relationship between systemic exposure, muscle exposure and myopathy
J. Sidaway;  Y. Wang;  A. M. Marsden;  T. C. Orton;  F. R. Westwood;  C. T. Azuma; R. C. Scott
Pages 90 – 98
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