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Xenobiotica
The fate and safety evaluation of foreign compounds in biological systems
, Volume
39
Issue 3 2009
ISSN:
1366-5928 (electronic) 0049-8254 (paper)
Publication Frequency:
12 issues per year
Subjects:
Pharmacology
;
Toxicology
;
Publisher:
Informa Healthcare
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Commentary
Drug–drug interaction studies in preclinical species: should metabolite(s) kinetics be studied?
N. R. Srinivas
Pages 193 – 196
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Research Article
2-ABT-
S
-oxide detoxification by glutathione
S
-transferases A1-1, M1-1 and P1-1: Implications for toxicity associated with zileuton
E. M. Joshi; B. H. Heasley; T. L. Macdonald
Pages 197 – 204
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Characterization of increased drug metabolism activity in dimethyl sulfoxide (DMSO)-treated Huh7 hepatoma cells
S. Choi; B. Sainz Jr.; P. Corcoran; S. Uprichard; H. Jeong
Pages 205 – 217
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Comparison of formation of thiolactones and active metabolites of prasugrel and clopidogrel in rats and dogs
K. Hagihara; M. Kazui; H. Ikenaga; T. Nanba; K. Fusegawa; M. Takahashi; A. Kurihara; O. Okazaki; N. A. Farid; T. Ikeda
Pages 218 – 226
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Utilization of estimated physicochemical properties as an integrated part of predicting hepatic clearance in the early drug-discovery stage: Impact of plasma and microsomal binding
C. Emoto; N. Murayama; A. Rostami-Hodjegan; H. Yamazaki
Pages 227 – 235
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o
-Nitroanilines as major metabolic products of anti-
Trypanosoma cruzi
5-phenylethenylbenzofuroxans in microsomal and cytosolic fractions of rat hepatocytes and in whole parasitic cells
M. Boiani; A. Merlino; A. Gerpe; W. Porcal; F. Croce; S. Depaula; M. A. Rodríguez; H. Cerecetto; M. González
Pages 236 – 248
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Effect of
Schisandra chinensis
extract and
Ginkgo biloba
extract on the pharmacokinetics of talinolol in healthy volunteers
L. Fan; X. -Q. Mao; G. -Y. Tao; G. Wang; F. Jiang; Y. Chen; Q. Li; W. Zhang; H. -P. Lei; D. -L. Hu; Y. -F. Huang; D. Wang; H. -H. Zhou
Pages 249 – 254
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Plasma pharmacokinetics and metabolism of the antitumour drug candidate 2′-benzoyloxycinnamaldehyde in rats
Kiho Lee; Byoung-Mog Kwon; Kangjeon Kim; Jekyung Ryu; Soo Jin Oh; Kye Sook Lee; Mu-Gil Kwon; Song-Kyu Park; Jong Soon Kang; Chang Woo Lee; Hwan Mook Kim
Pages 255 – 265
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Exploration of the African green monkey as a preclinical pharmacokinetic model: oral pharmacokinetic parameters and drug–drug interactions
K. W. Ward; D. J. Coon; D. Magiera; S. Bhadresa; M. Struharik; M. S. Lawrence
Pages 266 – 272
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Pharmacokinetics, tissue distribution, and metabolism of novel DNA topoisomerase I inhibitor yuanhuacine in rabbit
S. X. Zhang; P. W. Yang; D. C. Zhang; W. Q. Dong; F. H. Zhang; Y. M. Sun
Pages 273 – 281
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Acknowledgements
Acknowledgements
Page 282
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