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Xenobiotica The fate and safety evaluation of foreign compounds in biological systems, Volume 39 Issue 3 2009

Xenobiotica is moving!

ISSN: 1366-5928 (electronic) 0049-8254 (paper)
Publication Frequency: 12 issues per year
Subjects: Pharmacology; Toxicology;
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Commentary
Drug–drug interaction studies in preclinical species: should metabolite(s) kinetics be studied?
N. R. Srinivas
Pages 193 – 196
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Research Article
2-ABT-S-oxide detoxification by glutathione S-transferases A1-1, M1-1 and P1-1: Implications for toxicity associated with zileuton
E. M. Joshi;  B. H. Heasley; T. L. Macdonald
Pages 197 – 204
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Characterization of increased drug metabolism activity in dimethyl sulfoxide (DMSO)-treated Huh7 hepatoma cells
S. Choi;  B. Sainz Jr.;  P. Corcoran;  S. Uprichard; H. Jeong
Pages 205 – 217
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Comparison of formation of thiolactones and active metabolites of prasugrel and clopidogrel in rats and dogs
K. Hagihara;  M. Kazui;  H. Ikenaga;  T. Nanba;  K. Fusegawa;  M. Takahashi;  A. Kurihara;  O. Okazaki;  N. A. Farid; T. Ikeda
Pages 218 – 226
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Utilization of estimated physicochemical properties as an integrated part of predicting hepatic clearance in the early drug-discovery stage: Impact of plasma and microsomal binding
C. Emoto;  N. Murayama;  A. Rostami-Hodjegan; H. Yamazaki
Pages 227 – 235
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o-Nitroanilines as major metabolic products of anti-Trypanosoma cruzi 5-phenylethenylbenzofuroxans in microsomal and cytosolic fractions of rat hepatocytes and in whole parasitic cells
M. Boiani;  A. Merlino;  A. Gerpe;  W. Porcal;  F. Croce;  S. Depaula;  M. A. Rodríguez;  H. Cerecetto; M. González
Pages 236 – 248
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Effect of Schisandra chinensis extract and Ginkgo biloba extract on the pharmacokinetics of talinolol in healthy volunteers
L. Fan;  X. -Q. Mao;  G. -Y. Tao;  G. Wang;  F. Jiang;  Y. Chen;  Q. Li;  W. Zhang;  H. -P. Lei;  D. -L. Hu;  Y. -F. Huang;  D. Wang; H. -H. Zhou
Pages 249 – 254
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Plasma pharmacokinetics and metabolism of the antitumour drug candidate 2′-benzoyloxycinnamaldehyde in rats
Kiho Lee;  Byoung-Mog Kwon;  Kangjeon Kim;  Jekyung Ryu;  Soo Jin Oh;  Kye Sook Lee;  Mu-Gil Kwon;  Song-Kyu Park;  Jong Soon Kang;  Chang Woo Lee; Hwan Mook Kim
Pages 255 – 265
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Exploration of the African green monkey as a preclinical pharmacokinetic model: oral pharmacokinetic parameters and drug–drug interactions
K. W. Ward;  D. J. Coon;  D. Magiera;  S. Bhadresa;  M. Struharik; M. S. Lawrence
Pages 266 – 272
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Pharmacokinetics, tissue distribution, and metabolism of novel DNA topoisomerase I inhibitor yuanhuacine in rabbit
S. X. Zhang;  P. W. Yang;  D. C. Zhang;  W. Q. Dong;  F. H. Zhang; Y. M. Sun
Pages 273 – 281
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Acknowledgements
Acknowledgements
Page 282
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